Multidrug-Resistant (MDR-TB) & Extensively Drug-Resistant (XDR-TB) Tuberculosis Center
Standardized WHO regimens, molecular diagnostics, and dedicated therapeutic drug monitoring for complex tuberculosis.
Comprehensive referral center specializing in difficult, relapsed, and drug-resistant tuberculosis. Dr. Manoj S. Maske brings extensive academic and tertiary institutional experience from TNMC Nair Hospital in designing tailored second-line regimens with compassionate adherence support.
When Is This Care Recommended?
Treatment Failure on First-Line Anti-TB Drugs
Persistent positive sputum smears or deteriorating chest X-ray despite regular first-line ATT therapy.
Relapsed or Recurrent Tuberculosis
Return of cough, fever, and weight loss after completing a previous course of tuberculosis treatment.
Known Contact with Drug-Resistant TB Patient
Household or close contacts developing respiratory symptoms requiring rapid molecular resistance screening.
Extrapulmonary Drug-Resistant TB
Drug-resistant mycobacterial infection involving pleural effusion, lymph nodes, spine, or abdomen.
Severe Adverse Drug Reactions to ATT
Drug-induced hepatitis, severe skin rashes, optic neuropathy, or renal impairment requiring salvage regimen reformulation.
Co-morbid TB in Diabetes, Renal Failure or Elderly
Complex cases where drug interactions and altered pharmacokinetics require meticulous dosage titration.
Advanced Technology & Clinical Protocols
Molecular GeneXpert / CBNAAT Testing
Rapid DNA amplification detecting Mycobacterium tuberculosis and rifampicin resistance within 2 hours.
Line Probe Assay (LPA) & Culture DST
First-line and second-line drug susceptibility testing identifying resistance to Isoniazid, Fluoroquinolones, and Injectables.
Novel All-Oral BPaL / BPaLM Regimens
Implementation of modern shorter all-oral regimens containing Bedaquiline, Pretomanid, and Linezolid.
Multi-Organ Safety Monitoring Protocols
Structured baseline and monthly ECG (QTc tracking), audiometry, liver function tests, and thyroid monitoring.
Step-by-Step Clinical Journey
Definitive Molecular Drug Resistance Staging
Immediate sputum/tissue CBNAAT and liquid culture DST to map the exact drug sensitivity profile.
Individualized Regimen Formulation
Selecting a potent combination of 4 to 5 effective second-line agents conforming to international WHO guidelines.
Adherence & Nutritional Support Counseling
Dedicated counseling on adherence, family infection-control measures, protein nutrition, and symptomatic support.
Structured Sputum Conversion Surveillance
Monthly microbiological culture tracking until confirmed smear conversion and permanent microbiological cure.
Why Choose Icon Lung Clinic for this Speciality?
- In-depth clinical mastery led by Dr. Manoj S. Maske with hundreds of successfully cured drug-resistant cases.
- Complete access to modern all-oral shorter regimens with minimal injectable toxicity.
- Rigorous multi-organ safety monitoring ensuring protection against drug-induced liver or nerve damage.
- Compassionate family counseling and strict isolation guidance preventing household transmission.